Brighton and Hove Albion at home to Liverpool is another big matchup while Wrexham will be looking to create a fairytale run when they host Sheffield United. There is also shock potential in Fulham vs. Sunderland and Preston North End vs. Tottenham Hotspur so keep an eye on those two as well. We take a look at the main games this weekend. How to Watch FA CupYou can catch all the FA Cup fourth round action streaming live on ESPN+. Manchester City kick off the weekend's action on Friday at 3 p.
m. ET while Wrexham vs. Sheffield United will close the weekend on Sunday at 11:30 a. ET and Derby vs. West Ham will be on Monday at 2:45 p. ET. Friday: Manchester City vs. ArsenalIt does not get much bigger than first against second in the Premier League as the first of a two-part instalment over the next fortnight. The Gunners have a five-point lead which could stretch to eight if they can win their game in hand and Pep Guardiola's men have a tough task ahead of them if they are to stop Mikel Arteta's side from securing the crown. The FA Cup is perhaps not the most pressing of priorities for Arsenal given their lofty position while City joined them in being out of the running for the League Cup which puts added emphasis on the UEFA Champions League.
FA Cup - Preston North End v Tottenham Hotspur: Latest team
FA Cup preview: Manchester City vs. Arsenal live stream, how to watch online, everything you need to knowGetty Images It is FA Cup fourth round weekend and domestic cup action begins with a bang as Manchester City meet Arsenal in a battle between the Premier League's top two which will see only one advance.
Preston North End vs Tottenham Hotspur: FA Cup Live Stream
Matches on TV - Tottenham Hotspur